Find a 9-digit number, which you will gradually round off starting with units, then tenth, hundred etc., until you get to the last numeral, which you do not round off. The rounding alternates (up, down, up ...). After rounding off 8 times, the final number is 500000000. The original number is commensurable by 6 and 7, all the numbers from 1 to 9 are used, and after rounding four times the sum of the not rounded numerals equals 24.
I have one of the three numbers: 1, 2, or 3 in my mind. I speak only truth. You can ask me just one question for which I will only reply in yes or no or don't know. What question will you ask from me so that you are able to know the number?
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.