What question can you never answer yes to?

You are given a cube that is made with the help of 10x10x10 smaller cubes summing up to a total of 1000 smaller cubes. You are asked to take off one layer of the cubes.
How many remain now?

It is a nine-letter word.
The exact opposite of the phrase "friendly and outgoing"
It contains the word "over".
It starts will a vowel.

What is it?

Assume there are approximately 5,000,000,000 (5 billion) people on Earth. What would you estimate to be the result, if you multiply together the number of fingers on every person's left hand? (For the purposes of this exercise, thumbs count as fingers, for five fingers per hand.) If you cannot estimate the number then try to guess how long the number would be.

Some friends went on a vacation to a resort. It was raining heavily and it kept raining for thirteen days.

When it rained in the morning, the afternoon was beautiful and when it rained in the afternoon, the day was blessed with a clear morning.

Overall, the friends experienced eleven nice mornings and twelve nice afternoons. Can you find out the number of days they spent on vacation?

What seven-letter word has hundreds of letters in it?

Can you move 2 matchsticks to form four equal sized squares.

There is something which is always coming but never arrives?

I have nine bottles of wine and one of the nine bottles is poisoned.
I need to find the poisoned bottle with two facts
(1) Poison is deadly, only a sip will cost death
(2) I have two mice to do so.

How should I do it?

John and his wife were living in a rural place. On a particular day, John's wife fell ill and he called the local doctor. When the doctor picked up, he said, "Doctor, my wife is ill. She might have appendicitis."

"This can't be possible! I took out her appendix two years ago myself," the doctor explained.

When diagnosed, John's wife was found to have appendicitis. How can this be possible?