To tease, King Akbar told his most clever advisor Birbal to give his daughter one thing that she can eat when hungry, drink if she feels thirsty and can burn if she feels cold. King Akbar was shocked when Birbal gave Akbar's daughter one such thing that satisfies all of the above.
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.