The Puzzle: Here is a famous prize problem that Sam Loyd issued in 1882, offering $1000 as a prize for the best answer showing how to arrange the seven figures and the eight 'dots' .4.5.6.7.8.9.0. which would add up to 82
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.
