There are three boxes. One is labeled "APPLES" another is labeled "ORANGES". The last one is labeled "APPLES AND ORANGES". You know that each is labeled incorrectly. You may ask me to pick one fruit from one box which you choose.
There is a box in which distinct numbered balls have been kept. You have to pick two balls randomly from the lot.
If someone is offering you a 2 to 1 odds that the numbers will be relatively prime, for example
If the balls you picked had the numbers 6 and 13, you lose $1.
If the balls you picked had the numbers 5 and 25, you win $2.
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.