Here is a mathematical challenge that will not only engage your brain but also measure your quick-thinking abilities. If you can successfully identify the missing number in such a short span, you are demonstrating exceptional intellectual qualities.
A 3 digit number is such that it's unit digit is equal to the product of the other two digits which are prime. Also, the difference between it's reverse and itself is 396.
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.