Relationship in Numbers and Letters

If we tell you that there is a relation between the numbers and letters in the given figure, can you analyze it and find the missing letter in the last box?

Relationship in Numbers and Letters




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O_er_t_o_

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Gamers

In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.