I have one of the three numbers: 1, 2, or 3 in my mind. I speak only truth. You can ask me just one question for which I will only reply in yes or no or don't know. What question will you ask from me so that you are able to know the number?
If we tell you that there is a relation between the numbers and letters in the given figure, can you analyze it and find the missing letter in the last box?
In 2011, people playing Foldit, an online puzzle game about protein folding, resolved the structure of an enzyme that causes an Aids-like disease in monkeys. Researchers had been working on the problem for 13 years. The gamers solved it in three weeks.