Replace the question mark with the correct number.

Look at the below sequence of letters and tell us what the next letter should be:

O T T F F S S ?

The doctor advised his patient to take a tablet after every fifteen minutes. He gave him five tablets in total.

How much time will he take to have all the five tablets?

John has played 50 ODI's and his average is 50. How many runs should he score in his 51st ODI, so that his average score jumps to 51?

Using the clues below, what four numbers am I thinking of?

The sum of all the numbers is 31.
One number is odd.
The highest number minus the lowest number is 7.
If you subtract the middle two numbers, it equals two.
There are no duplicate numbers.

A thief is convicted in Mexico. He gets the death penalty. The judge allows him to say the last sentence to determine how the penalty will be carried out. If the thief lies, he will be hanged, if he speaks the truth he will be beheaded. The thief tells the last sentence and to everybody's surprise some minutes later he is set free because the judge cannot determine his penalty. What did the thief say?

I have one of the three numbers: 1, 2, or 3 in my mind. I speak only truth. You can ask me just one question for which I will only reply in yes or no or don't know. What question will you ask from me so that you are able to know the number?

Kohli and Dhoni decided to have a paintball match.
Kohli told Dhoni, "Sir it is not right as you got thrice the paintballs I have".

Dhoni instantly gives Kohli 10 hit paintballs.
Kohli replied, "Sir, I believe you still have twice the paintballs than I have".

Dhoni gives "?" more paintballs to Kohli.
Kohli replied, "Sir it is even now, Let us have a match".

What is "?".

In a science lab, a petri dish hosts a healthy colony of yeast for an experiment. Now every minute, all the yeast cells divide into two. At noon, there was just a single cell of yeast and at 1:22, the Petri dish was half full. Can you calculate when the dish will be full of yeast?

On a certain day, John celebrated his birthday. Two days later, his older twin brother Jacob celebrated his birthday.

Is this even possible? How can it be?